Akuamma Seeds (Picralima nitida) is a tree and native to West Africa. The dried seeds from this plant are used in traditional medicine throughout West Africa, particularly in Ghana as well as in the Ivory Coast and Nigeria. The seeds are crushed or powdered and taken orally. Akuamma seeds have opioid analgesic activity and is often used a painkiller. There are five alkaloids in Akuamma seeds : akuammidine, akuammine, akuammicine, akuammigine and pseudo-akuammigine) .
Akuammine is the main alkaloid found in the seeds, comprising 0.56% of the dried powder. It is structurally related to both yohimbine and mitragynine, both of which are alkaloid plant products with uses in medicine. Akuammine is the most abundant active alkaloid found in the seeds from the tree Picralima nitida, commonly known as Akuamma.
(An enterprising Ghanaian hospital started manufacturing standardised 250mg capsules of the powdered P. nitidaseed, and sold them around the country where they became widely accepted as a safe and effective pain relief product. This then led researchers to try and discover the active component of the seeds.) Read More
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